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Vendredi 16 Septembre 2011

Information  sur  le  rôle  des 
Per  Oxydes  d'Azote *
* Gaz d'échappements et gaz issus de processus industriels

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Product Details

• Hardcover: 265 pages
• Publisher: Springer; 1 edition (April 30, 2004)
• Language: English
• ISBN-10: 140207736X
• ISBN-13: 978-1402077364
• Product Dimensions: 11.3 x 8.4 x 0.9 inches

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FOREWORD

Nitric oxide (NO) is one of the most remarkable biological molecules characterized at the turn of XXth century. Small in size, but ubiquitous and complex in its network of molecular, cellular and organ interactions, NO plays an important role in mammalian and non-mammalian biology. The scope and versatility of NO actions on the biological systems range from neuromodulation and regulation of cardiovascular homeostasis to cell signaling and immunity. An impressive array of physiologic and pathologic reactions  are controlled by or associated with changes in the biological specter of NO.

The “career” of NO in science started from a handful of publications written before 1986 to more than 52,000 contributions at the end of 2002 (Pubmed, National Library of Medicine). More than 15,000  publications deal with the effects of NO in the cardiovascular system. The NO field has been recently

knighted with the 1998 Nobel Prize in Medicine awarded to R.F. Furchgott, F. Murad and L.J. Ignarro.

This book attempts to present the state-of-the-art knowledge on the role of NO in cardiovascular homeostasis and in the pathogenesis of heart failure and diseases that underlie the development of heart failure. In the United States, heart failure, a multifactorial pathophysiologic state, which complicates the clinical course of many cardiovascular diseases, is responsible for close to 1,000,000 hospital admissions and 40,000 deaths annually. The book has 20 chapters highlighting the role of NO in the pathophysiology and therapeutics of heart failure. Book chapters have been written both by clinicians and basic scientists to emphasize the translational character of the contemporary NO research. A broad cross-section of presented topics includes discussion of basic cardiovascular physiology, as well as of pathophysiology and “cutting edge” pharmacology of heart failure. Considerable attention has been paid to interactions between NO and other players on the cardiovascular arena including peptides and proteins such as angiotensins, natriuretic peptides, matrix metalloproteinases, and free radicals including superoxide and peroxynitrite.

In the age of proteomics and combinatorial chemistry, the elucidation of interactions between NO synthase and other bioactive enzymes and proteins may contribute to better understanding and treatment of heart failure.

Marek W. Radomski

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Mais aussi un autre article  avec Source INSERM LYON:

" Notre  santé ". 

sur le Blog la-ligue-chretienne-01.blogspot.com 

Facteurs Environnementaux à la source des Diabètes de type 2.

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